4 This may be why DIM was found to have anti-cancer effects of androgen-sensitive prostate cancer cells.Īndrogen hormones play a role in the formation of acne. These results suggest that DIM may be a unique bifunctional hormone disruptor and one of the first known plant-derived androgen receptor antagonists. Receptor binding assays also show that DIM is a powerful competitive inhibitor of DHT binding to androgen receptors. Studies have found that plant-derived DIM may exhibit powerful anti-androgenic and anti-proliferative properties in human prostate cancer cells.ĭIM was shown to suppress the proliferation of cancerous cells while inhibiting the stimulation of DHT, a hormone commonly associated with hair loss and benign prostatic hyperplasia (an enlarged prostate). While DIM may not be helpful for building muscle mass, studies suggest that DIM may promote prostate health and prevent prostate cancer. The results from these two studies mean that DIM may actually lower testosterone levels and make it harder to build muscle. This suggests that the increase in muscle mass in response to resistance training may depend less on testosterone levels and more on the number of androgen receptors in the muscles. More interestingly, the differences in intramuscular androgen receptor content were significantly greater in the high responder group than the low responder group, correlating with changes in overall muscle mass. When looking at the men who had a hard time gaining muscle (high responders) and easy gainers (low responders), researchers found no significant differences in in intramuscular testosterone or DHT, though results did show significant changes in 5-alpha reductase expression in the high responder group. While both groups showed increased muscle mass, there were no significant hormonal differences between either repetition group for any outcomes. Researchers took blood samples and performed hormonal analyses. The study lasted 12 weeks, during which each volunteer performed a whole body resistance exercise training routine four days per week and received 30 grams of whey protein per day. The high repetition group performed exercised with low resistance but a larger number of repetitions until volitional failure, while the low repetition group performed exercises with a relatively heavy resistance with fewer repetitions until volitional failure. In one study, 49 resistance-trained young men were randomly placed into either a high repetition or low repetition group. This means that DIM may actually make it harder to gain muscle mass. This means that it lowers the number of testosterone receptors. Furthermore, it also lowers the expression of androgen receptors in testicular and prostate tissue. However, DIM appears to block both testosterone and estrogen. Going with this reasoning men take DIM with the hopes of blocking estrogen or boosting testosterone. 2ĭo higher testosterone levels correlate with increased muscle growth? The anecdotal evidence says so as steroids are commonly used to increase muscle growth. This suggests that DIM may actually have estrogen and testosterone blocking affects at lower doses. DIM at 10mg/kg also lowered the number of androgen receptors expressed in testicular and prostate tissue. That dose did not affect sperm growth or testicular tissue. It also lowered estrogen levels from 8.00 pg/mL in controls to 4.56 pg/mL. In the study DIM at 10 mg/kg (a dose of 700 mg for the average 70 kg man) slightly lowered testosterone levels from 4.77 ng/mL in control subjects to 3.81 ng/mL. Researchers monitored spermatological parameters as well as serum testosterone and estradiol levels. The control group received corn oil, while the other three received varying amounts of DIM for a study period of 53 days. In one study, 38 male rats were split into four different groups. Does DIM boost testosterone production? Let’s find out. One of the reasons why many men choose to take DIM supplements is to boost testosterone production for athletic and bodybuilding purposes. Let’s take a look at the research to see if DIM can actually do these things.ĭIM may affect hormones in both men and women. DIM has been reported to boost testosterone, help with prostate cancer, and help acne. DIM, or diindolylmethane, is a compound that forms in the body from the breakdown of plant substances, most commonly cruciferous vegetables, including broccoli, cabbage, cauliflower, and Brussels sprouts.
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